Rose is a fifth grader who lives with her father in rural New York. She has Asperger’s Syndrome and an aide helps her in the classroom. Rose is obsessed with homophones and prime numbers. She keeps lists of both and shouts them out when she’s agitated.Rose’s father has a hard time dealing with her endless questions and teacher conferences. He tries, but Rose feels closer to her dog Rain (Reign) and her Uncle Weldon. When a superstorm hits the area, Rain gets lost.
In 1901, two boys become friends in eastern Canada. Benji is a black youth who intends to become a newspaperman. His pal is a red-haired Irish boy named Alvin. Alvin wants to become a scientist. The duo met at a forensics competition. Benji has landed an apprenticeship with a local newspaper and is always thinking of his next story. Alvin lives with his father and Grandma. While exploring the woods, they encounter the “Madman of Piney Woods,” who turns out to be a Civil War veteran who has become a hermit.
Edmund is an only child living in Manhattan with his parents. He is a talented artist, and with his photographic memory, he is able to make remarkable sketches of people. Hence, he is recruited by the police department to draw people he sees in art museums who might be part of an art theft ring. His police handler is Detective Bovano, who keeps Edmund safe during the investigation.
Flora is a happy, curious pig who lives with her mom and siblings on a farm. She longs for adventure, but there isn’t much going on in the pigpen. One day, she makes an escape and tastes the joy of freedom. When she spies some dogs training for sled-pulling, she dreams of joining the team.